Research

Direct delivery of anti-IL6 Mabs to the lungs

Roche initiates Phase III clinical trial of Actemra/RoActemra in hospitalised patients with severe COVID-19 pneumonia

• https://clinicaltrials.gov/ct2/show/NCT04320615
• https://www.cell.com/cell-host-microbe/pdf/S1931-3128(20)30236-5.pdf

An Adaptive Phase 2/3, Randomized, Double-Blind, Placebo-Controlled Study Assessing Efficacy and Safety of Sarilumab for Hospitalized Patients With COVID-19

• https://clinicaltrials.gov/ct2/show/NCT04315298

A Phase I/II Study of Universal Off-the-shelf NKG2D-ACE2 CAR-NK Cells Secreting IL15 Superagonist and GM-CSF-neutralizing scFv for Therapy of COVID-19

RT-PCR and IgM/IgG test kits now available

New assay to detect presence of IgM and IgG against SARS-CoV-2 virus with peripheral blood (i.e. fingersticks)

Antibody responses to SARS-CoV-2 in patients with COVID-19

Zydus explores the biologicals route to treat novel Coronaviruswith long-acting Interferon alpha-2b

A Phase 2/3, Randomized, Open-label, Parallel Group, 3-arm, Multicenter Study Investigating the Efficacy and Safety of Intravenous Administrations of Emapalumab, an Anti-interferon Gamma (Anti-IFNγ) Monoclonal Antibody, and Anakinra, an Interleukin-1(IL-1) Receptor Antagonist, Versus Standard of Care, in Reducing Hyper-inflammation and Respiratory Distress in Patients With SARS-CoV-2 Infection.

A Phase 2/3, Randomized, Open-label, Parallel Group, 3-arm, Multicenter Study Investigating the Efficacy and Safety of Intravenous Administrations of Emapalumab, an Anti-interferon Gamma (Anti-IFNγ) Monoclonal Antibody, and Anakinra, an Interleukin-1(IL-1) Receptor Antagonist, Versus Standard of Care, in Reducing Hyper-inflammation and Respiratory Distress in Patients With SARS-CoV-2 Infection.

Idronoxil inhibits a key inflammatory pathway involved in a process known as a cytokine storm, which is associated with an abnormally excessive inflammatory response and is believed to be responsible for most deaths in patients with COVID-19 infection

• https://www.noxopharm.com/site/PDF/6ddda156-2885-4417-ba1f-9e520f1cb085/NoxopharmInvestigatingPotentialCOVID19Treatment
• https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30628-0/fulltext

Phase 3 RUXCOVID Study Evaluating Ruxolitinib (Jakafi®) as a Treatment for Patients with COVID-19 Associated Cytokine Storm

• https://clinicaltrials.gov/ct2/results?cond=COVID-19&term=Ruxolitinib&cntry=&state=&city=&dist=&Search=Search

Angiotensin-(1,7) Treatment in COVID-19: the ATCO Trial (ATCO)

MediciNova Announces Plans to Initiate a Clinical Trial of MN-166 (ibudilast) for COVID-19 Acute Respiratory Distress Syndrome (ARDS)

In seven patients (four female), regardless of anticoagulation status, all autopsies demonstrated platelet-rich thrombi in the pulmonary, hepatic, renal, and cardiac microvasculature. Megakaryocytes were seen in higher than usual numbers in the lungs and heart.

MesenCure was developed for the treatment of acute and life-threatening respiratory distress in coronavirus (COVID-19) and pneumonia patients. MesenCure consists of activated Mesenchymal Stromal Cells (“MSCs”) that are isolated from the adipose tissue of healthy donors.

• https://www.bonusbiogroup.com/index.php/news-media/press-releases/item/32-bonus-biogroup-has-initiated-a-preclinical-study-of-a-unique-drug-developed-for-the-treatment-of-life-threatening-respiratory-distress-in-corona-covid-19-patients-and-pneumonia

Replicating Viral Vector currenly in preclinical testing

• http://www.globenewswire.com/news-release/2020/02/26/1990820/0/en/Tonix-Pharmaceuticals-Announces-Research-Collaboration-with-Southern-Research-to-Develop-a-Potential-Vaccine-to-Protect-Against-New-Coronavirus-Disease-2019-COVID-19-Based-on-Horse.html

Non-human primate model of COVID-19 infection to explore therapies, vaccines and effect of age

UCSF Researchers Aim to Enroll One Million Individuals for Real-Time Epidemiology

Reseach of how SARS-CoV-2 hijacks human cells for its own replication

To develop prophylactic/therapeutic antibody preparations

Testing and Analysis of SARS-CoV-2 protective gear

Development of diagnostic tools for SARS-CoV-2

Exploring inflammation in murine model of SARS-CoV-2 infection and vaccine development

Genomic sequencing of SARS-CoV-2